In 1664, Madame de Lestonnac bequeathed the domaine of La Mission Haut-Brion to the Peres Lazaristes, a congregation founded by Saint Vincent de Paul. The "good fathers" worked to restore their property to its rightful worth. After them, the Chiapella family (owners in the 19th century) and Woltner family (1919-1983) never stopped improving the vineyard and modernizing the cellars. Since 1983, the Dillon family, already owner of Chateau Haut-Brion, continues the same policy under the presidency of H.R.H. Prince Robert of Luxembourg. Chateau La Mission-Haut-Brion is the greatest Graves wine after Haut-Brion and in some vintages is considered the superior wine of the two. La Mission-Haut-Brion is situated just across the road from Haut-Brion in the commune of Talence in the southern suburbs of Bordeaux.

La Mission-Haut-Brion's vineyards (Cabernet Sauvignon 48%, Merlot 45%, Cabernet Franc 7%) lie on a large (up to 18 metres deep in places) gravel bank interspersed with clay. The wine is fermented in temperature-controlled, stainless steel vats and then matured in oak barriques (100% new) for 18 months. The wines of La Mission Haut Brion are rich, oaky and powerful and need at least 10 years of bottle ageing before they should be broached.